Meet a Mass General Postdoc: Robert Lochhead

This week is National Postdoc Appreciation Week, a time to recognize the significant contributions that postdoctoral scholars make to the research community.

In celebration, all this week we’ll be sharing profiles of just a few of the amazing postdocs here at Mass General to highlight their research and what inspires them.

First, we’d like to introduce Robert Lochhead, a clinical research fellow for the Center for Immunology and Inflammatory Diseases in the Division of Rheumatology, Allergy & Immunology:

Postdoc week Lochhead.png

Where did you get your PhD from?

I got my PhD in microbiology and immunology from the University of Utah School of Medicine.

What questions are you asking in your current research?

I am studying the immunopathology of Lyme arthritis, and the relationship between infection and autoimmunity.

What do you hope to find out?

From a microbial and immunological perspective, Lyme disease is a fascinating human infectious disease model. The pathogen, Borrelia burgdorferi, is highly adapted to hiding from the immune system within connective tissue, resulting in infections that can go undetected for many months. What’s more, there is a wide range of disease manifestations and severity, depending on both host and pathogen factors. Lyme arthritis, the most common late-disease manifestation, may persist or worsen even after the bacteria have been cleared by antibiotic therapy, called post-infectious Lyme arthritis. My research is focusing on how B. burgdorferi infection and subsequent tissue damage may trigger chronic autoimmune arthritis, with the hope of determining mechanisms of how infection may induce autoimmunity.

What drew you to this field?

As a young graduate student interested in host-pathogen interactions, I was attracted to the immunology of Lyme arthritis as a model of studying infection-induced autoimmunity. I’ve stuck with Lyme disease ever since, first in mouse models as a graduate student, now in humans as a postdoc.

What is a typical day like for you?

I spend most of my time analyzing big RNA sequencing datasets, in the microscope room, collecting and processing clinical samples, and writing grant applications and manuscripts. Right now my typical day is mostly writing.

What do you like most about being a postdoc at MGH?

Without a doubt, the best thing about being a postdoc here at MGH is the opportunity to collaborate with wonderful clinicians and patients who are so invested in the research side of human disease. Seeing the impact of these diseases on patients brings an urgency and focus to my research that will certainly shape the rest of my scientific career.

Author: mghresearch

The Massachusetts General Hospital Research Institute is the largest hospital-based research program in the United States, with a community of over 8,000 people working across more than 30 institutes, centers and departments.

Our researchers work side-by-side with physicians to pioneer the latest scientific advancements for curing disease and healing patients in Boston, across the United States and around the world.

Leave a Reply