Category: Genetics and Genomics Research

Tumor RNA Within Platelets May Help Diagnose and Classify Cancer, Identify Treatment Strategies

“By combining next-generation-sequencing gene expression profiles of platelet RNA with computational algorithms we developed, we were able to detect the presence of cancer with 96 percent accuracy,” says Bakhos Tannous, PhD, of the MGH Department of Neurology, co-senior author of the Cancer Cell paper along with investigators from VU University Medical Center in Amsterdam. READ MORE

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Mass. General Study Identifies Genomic Differences Between Breast Cancers of African American and White Women

“In addition to having a higher prevalence of triple-negative breast cancers than Caucasian women – something that has been documented in previous studies – we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor […]

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Newly Identified Gene Variants that Modify the Onset of Huntington’s Disease Could Lead to New Therapeutics

Researchers from the Mass General Research Institute have used an innovative approach to pinpoint two locations on the human genome that influence the rate at which Huntington’s disease (HD), a debilitating neurodegenerative disorder, develops in those carrying the HD gene defect. By studying the samples from more than 4,000 HD patients, researchers were able to identify two genetic variants in […]

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Could the Ocean Lead the Way to New Cancer Treatments and Antibiotics?

Aging physicians, secrets to disease treatment from the ocean floor and genetic sequencing of Ebola are just a few topics covered in the latest issue of Mass General’s Proto Magazine: Dispatches From the Frontiers of Medicine, online now. LEARN MORE

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