Category: Genetics and Genomics Research

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Biobank Reveals Novel Research Kiosks

At the Partners HealthCare Biobank, everyone has the ability to help shape the future of healthcare. The Biobank is a research initiative that brings patients, clinicians, and investigators together to make research discoveries that improve care for generations to come. Patients are asked to provide consent, a blood sample, and take a health survey. These […]

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Raising Awareness of Belly Fat and Its Impact on Men’s Health

Did you know that in addition to June being Men’s Health Month in the United States, this week (June 12th-18th) is Men’s Health Week in the UK? The focus this year is on belly fat which tends to be more prevalent in men than women. Regardless of a person’s overall weight, belly fat—also called abdominal […]

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Missing Genes Point to New Drug Targets

The Human Genome Project provided a ‘parts-list’ of genes, about 18,000 in number. Now, researchers are studying what it means to be missing a part. In an analysis of the genomes of 10,000 research participants, Mass General’s Dr. Sekar Kathiresan and his research team found 1,300 genes which were broken in at least one participant. […]

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Genetic Study Identifies Link Between Body Shape and Risk of Heart Disease and Diabetes

When you put on weight, do the pounds show up at your waistline or on your hips? The answer could have long-term implications for your risk of developing coronary heart disease (CHD) and Type 2 diabetes. Learn how Massachusetts General Hospital researchers identified a link between body shape and risk of heart disease and diabetes.

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Genetic Studies Reveals New Clues to Hereditary High Blood Pressure

High blood pressure is a major cause of heart disease and stroke. We know that half the risk of developing high blood pressure is due to inherited factors, but until recently we only understood two percent of the genetic reasons for that risk. But researchers at Massachusetts General Hospital are now a step closer to understanding the genetic underpinnings […]

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Partners Biobank Plays Key Role in Research

Sekar Kathiresan, MD, medical director for the Cardiology Division, and his team of investigators – led by cardiologist Pradeep Natarajan, MD, and research coordinator Erina Kii in the Center for Human Genetic Research – are looking for a needle in a haystack. LEARN MORE

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The Science Behind The Perception Of Beauty

When it comes to who you find attractive, a new Mass General research study suggests that environment and experience may have more influence than your genetic makeup. The online study, led by Laura Germine, PhD, used sets of twins to estimate the relative contributions of genetic and environmental variation when judging attractiveness of a series […]

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Tumor RNA Within Platelets May Help Diagnose and Classify Cancer, Identify Treatment Strategies

“By combining next-generation-sequencing gene expression profiles of platelet RNA with computational algorithms we developed, we were able to detect the presence of cancer with 96 percent accuracy,” says Bakhos Tannous, PhD, of the MGH Department of Neurology, co-senior author of the Cancer Cell paper along with investigators from VU University Medical Center in Amsterdam. READ MORE

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Mass. General Study Identifies Genomic Differences Between Breast Cancers of African American and White Women

“In addition to having a higher prevalence of triple-negative breast cancers than Caucasian women – something that has been documented in previous studies – we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor […]

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Newly Identified Gene Variants that Modify the Onset of Huntington’s Disease Could Lead to New Therapeutics

Researchers from the Mass General Research Institute have used an innovative approach to pinpoint two locations on the human genome that influence the rate at which Huntington’s disease (HD), a debilitating neurodegenerative disorder, develops in those carrying the HD gene defect. By studying the samples from more than 4,000 HD patients, researchers were able to identify two genetic variants in […]

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