Thank You Postdocs!

As National Postdoc Appreciation Week comes to a close, we want to thank postdocs across the country, and especially those at Mass General, for all their hard work and dedication to research and scientific discovery.

Here at Mass General, we have over 1800 postdoctoral fellows who collectively contribute to over 6100 active research projects.

Earlier this week we celebrated our postdoc cohort with an ice cream social and asked them what they love most about research. Here’s what a few of them had to say…

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Meet a Mass General Postdoc: Amy Tsurumi

In honor of National Postdoc Appreciation Week, all this week we’ll be sharing profiles of just a few of our amazing Mass General postdocs to highlight their research and what inspires them.

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Our fourth and final featured postdoc this year is Amy Tsurumi, PhD, a research fellow in the Rahme Lab.

Where did you get your PhD from?

University of Rochester School of Medicine and Dentistry

What questions are you asking in your current research? What do you hope to find out?

My research is elucidating epigenetic mechanisms of host susceptibility and response to infections using Drosophila, mice and tissue culture Pseudomonas aeruginosa infection models.  I hope to identify specific histone post-translational modification marks and genomic loci that are relevant and explore the possibility of alleviating the negative impact of pathogenic encounters by reversing these epigenetic marks.  Given the rise of antibiotic resistant bacteria, developing host-targeted methods as an alternative approach may be significant.  I also conduct epidemiological and biomarker studies for prediction of vulnerability to infections and infections-related outcomes in burn and trauma patient cohorts. 

What drew you to this field?

My father was a physician-scientist with a microbiology research background and fascination in human genetics, so I grew up being curious about the field of biomedical sciences.  As a graduate student, I learned about epigenetics for the first time and studied histone lysine demethylases, a relatively novel class of epigenetic regulators back then, which I found to be absolutely exciting.  I was thrilled to join the Rahme lab where I was lucky to have been given the opportunity to continue to conduct epigenetics research that I am interested in, but shift from the context of Drosophila development to host-microbe interactions using a variety of model organisms and also incorporate patient cohort clinical research.

What is a typical day like for you?

It is difficult to define a “typical” day, which I actually enjoy. Most days, I spend the majority of the time running experiments on the bench or conducting patient data analyses.  When there are grant/fellowship deadlines, I spend the day focusing on writing.  I find myself to be extremely lucky that there are many different types of experimental methods I get to do and various model organisms available in the Rahme lab.  The variety of techniques offered has given me an incredible learning experience thus far.

What do you like most about being a postdoc at MGH?

I am awed by the highly collaborative environment at MGH.  The Rahme lab is diverse in terms of scientific background (and home countries!) and I am very thankful to my mentor for the excellent mentorship and also to other postdocs around me, especially labmates and floormates for the invaluable input and help I receive daily.  I also feel fortunate to be part of collaborative projects with various PIs within MGH and around the globe, as well as the vast amount of resources offered by neighboring labs, MGH core facilities and other Harvard campuses.  All the research that goes on every day at MGH is stimulating and my mentor and colleagues I have the opportunity to work with are inspiring.

Meet a Mass General Postdoc: Xavier Fernando Vela Parada

In honor of National Postdoc Appreciation Week, all this week we’ll be sharing profiles of just a few of our amazing Mass General postdocs to highlight their research and what inspires them.

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Xavier Fernando Vela Parada is a research fellow in the Thadhani Lab in the Nephrology Division.

Where did you get your MD from?

I studied medicine in my home country El Salvador, Central America.

What questions are you asking in your current research? What do you hope to find out?

At the Thadhani lab we focus on finding new ways to detect and treat various forms of kidney disease. We hope that we will be able to find new markers and new therapeutic agents that will allow us to treat and detect kidney disease in its early stages as well as its complications.

What drew you to this field?

Nephrology is the basis of medicine. Since I was in med school I was impressed at the way the kidneys tightly regulate the human physiology; this was my favorite subject while studying to become a physician. Chronic kidney disease is problem of enormous proportions and I feel committed to work towards finding a solution for our patients.

What is a typical day like for you?

A typical day will include discussion with my PIs about new research questions and future directions for our research. Also, when working with patients I make sure they understand how much we value them and how important their contribution is to science. I also work closely with other staff, making sure our study samples are collected and stored properly. Normally I will also reach out to younger staff to share my passion for kidney research.

What do you like most about being a postdoc at MGH?

I love the fact that being at MGH gives me the exposure to a vast array of fantastic clinicians, scientists, service and administrative personnel. Each one of them contribute in one way or another in order to achieve our end goal which is to improve patient care. At the same time MGH made me feel welcome from the very first day; in a place so diverse like this I encountered a new family.

Meet a Mass General Postdoc: Echoe Bouta

In honor of National Postdoc Appreciation Week, all this week we’ll be sharing profiles of just a few of our amazing Mass General postdocs to highlight their research and what inspires them.

Meet Echoe Bouta, PhD, a research fellow in the Department of Radiation Oncology.

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Where did you get your PhD from?

University of Rochester

What questions are you asking in your current research? What do you hope to find out?

Lipedema is a chronic disorder that results in increased fat in the lower limbs and manifests as dramatic, painful swelling. Clinical studies demonstrate that patients present with at least partial lymphatic dysfunction, which worsens until lymphedema occurs. As the etiology is largely unknown, treatments are often ineffective, demonstrating the need to understand the relationship between fat and lymphatic capability.  The questions I hope to answer are:

      •  How does increased adiposity impair lymphatic function in an animal model of obesity?
      • Can we target key pathways in this process to improve lymphatic function?

The answer to this questions will hopefully catalyze new treatments for lipedema.

What drew you to this field?

The lymphatic research field is relatively young compared to other research fields.  I believe that we have only started to discover the importance of the lymphatic system in multiple disease states and it is exciting to be part of that.

What is a typical day like for you?

Much of my project involves imaging of the lymphatic system under different contexts, such as obesity or after delivery of a drug. Therefore, a typical day for me is a mix of in vivo experiments, data analysis and writing.

What do you like most about being a postdoc at MGH?

The people.  We are surrounded by talented scientists from a variety of fields that results in a very interdisciplinary research environment.

Meet a Mass General Postdoc: Robert Lochhead

This week is National Postdoc Appreciation Week, a time to recognize the significant contributions that postdoctoral scholars make to the research community.

In celebration, all this week we’ll be sharing profiles of just a few of the amazing postdocs here at Mass General to highlight their research and what inspires them.

First, we’d like to introduce Robert Lochhead, a clinical research fellow for the Center for Immunology and Inflammatory Diseases in the Division of Rheumatology, Allergy & Immunology:

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Where did you get your PhD from?

I got my PhD in microbiology and immunology from the University of Utah School of Medicine.

What questions are you asking in your current research?

I am studying the immunopathology of Lyme arthritis, and the relationship between infection and autoimmunity.

What do you hope to find out?

From a microbial and immunological perspective, Lyme disease is a fascinating human infectious disease model. The pathogen, Borrelia burgdorferi, is highly adapted to hiding from the immune system within connective tissue, resulting in infections that can go undetected for many months. What’s more, there is a wide range of disease manifestations and severity, depending on both host and pathogen factors. Lyme arthritis, the most common late-disease manifestation, may persist or worsen even after the bacteria have been cleared by antibiotic therapy, called post-infectious Lyme arthritis. My research is focusing on how B. burgdorferi infection and subsequent tissue damage may trigger chronic autoimmune arthritis, with the hope of determining mechanisms of how infection may induce autoimmunity.

What drew you to this field?

As a young graduate student interested in host-pathogen interactions, I was attracted to the immunology of Lyme arthritis as a model of studying infection-induced autoimmunity. I’ve stuck with Lyme disease ever since, first in mouse models as a graduate student, now in humans as a postdoc.

What is a typical day like for you?

I spend most of my time analyzing big RNA sequencing datasets, in the microscope room, collecting and processing clinical samples, and writing grant applications and manuscripts. Right now my typical day is mostly writing.

What do you like most about being a postdoc at MGH?

Without a doubt, the best thing about being a postdoc here at MGH is the opportunity to collaborate with wonderful clinicians and patients who are so invested in the research side of human disease. Seeing the impact of these diseases on patients brings an urgency and focus to my research that will certainly shape the rest of my scientific career.