Adhering to Treatment During Adolescence Keeps HIV-Positive Youth on Healthier Track

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As HIV therapies have improved in recent decades, we are now seeing the first generation of youth who were born with the disease, or acquired it shortly after birth, live to adulthood. As this population matures, researchers are looking to learn more about how these individuals have fared in managing their condition in order to improve long-term treatment and care.

A recent Massachusetts General Hospital study of 1,400 individuals between the ages of 7 and 30 born with HIV found that teens and young adults are more likely to have a difficult time managing their condition than they did as younger children. Those in the study group who had good HIV control generally experienced good overall health outcomes, while those who had poor HIV control – meaning higher levels of HIV virus and lower levels of CD4 immune cells had more physical and mental health conditions, a higher incidence of health complications, and a greater risk of death.

“Adolescents infected with HIV – either at birth or later in life – experience poorer health outcomes compared to adults with HIV in nearly every respect”, says Anne Neilan, MD, MPH, of the Division of Infectious Diseases and the Medical Practice Evaluation Center, who led the study. “We need to act to strengthen these services for youth, taking into account their developmentally specific needs. That might include youth-friendly services that consider the substantial stigma many of these patients face, novel approaches to antiretroviral therapy delivery, and improving support for youth transitioning from pediatric to adult health care providers.”

Andrea Ciaranello, MD, MPH, of the Massachusetts General Hospital Division of Infectious Diseases and the Medical Practice Evaluation Center, is senior author of the study. Anne Neilan, MD, MPH, of the Division of Infectious Diseases and the Medical Practice Evaluation Center, led the study. Read more about this study here.

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