Mass. General Study Identifies Genomic Differences Between Breast Cancers of African American and White Women

“In addition to having a higher prevalence of triple-negative breast cancers than Caucasian women – something that has been documented in previous studies – we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,” says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study. “The higher risk of tumor recurrence that we observed among African American women was reduced when controlling for those factors, suggesting that these genomic differences contribute, at least partly, to the known racial disparity in the survival of African American and Caucasian breast cancer patients.”

 

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