Mass General Researchers Find Evidence of Neuroinflammation in Cases of Chronic Pain

A Mass General research study published earlier this year found—for the first time—evidence of neuroinflammation in the brain in patients with chronic pain. The study showed that levels of an inflammation- linked protein were elevated in regions of the brain known to be involved in the transmission of pain.

The discovery could make it possible to explore new treatments for chronic pain and
to find an objective way to measure the presence and/or intensity of chronic pain.

The inability to objectively measure chronic pain has been one of the most frustrating limitations on chronic pain treatment and research. Marco Loggia, PhD, of the Martinos Center for Biomedical Imaging is the lead author
of the study.

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